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Recent Research

A selection of relevant Publications, both basic and applied, is listed below and represents exciting work in Advanced Medical Technologies performed at NC State.

Relevant Theses and Dissertations are listed below.  Click on an author's name to read the abstract or download the full document (.pdf).

To locate additional research, visit NCSU Libraries' searchable NCSU Scholarly Publications Repository and Electronic Theses and Dissertations databases.

IP available for licensing that may interest medical technology enterprises is featured on our Licensing Opportunities page. The Office of Technology Transfer maintains a detailed listing of NCSU's IP portfolio in the searchable Tech Finder Database.

Publications

Adams, B. M., Banks, H. T., Davidian, M., & Rosenberg, E. S. (2007). Estimation and prediction with HIV-treatment interruption data. Bulletin of mathematical biology, 69(2), 563-584.

Bernacki, S. H., Wall, M. E., & Loboa, E. G. (2008). Isolation of human mesenchymal stem cells from bone and adipose tissue. Methods in cell biology, 86, 257-278.

Cansizoglu, O., Harrysson, O. L. A., West, H. A., Cormier, D. R., & Mahale, T. (2008). Applications of structural optimization in direct metal fabrication. Rapid prototyping journal, 14(2), 114-122.

Chang, S. T., Beaumont, E., Petsev, D. N., & Velev, O. D. (2008). Remotely powered distributed microfluidic pumps and mixers based on miniature diodes. Lab on a chip, 8(1), 117-124.

DeLisa, M., & Haugh, J. (2008). First International Conference on Biomolecular Engineering (ICBE). Biotechnology progress, 24(1), 1-1.

Devkota, A. C., Tsuzaki, M., Almekinders, L. C., Banes, A. J., & Weinhold, P. S. (2007). Distributing a fixed amount of cyclic loading to tendon explants over longer periods induces greater cellular and mechanical responses. Journal of orthopaedic research, 25(8), 1078-1086.

Finger, A. R., Sargent, C. Y., Dulaney, K. O., Bernacki, S. H., & Loboa, E. G. (2007). Differential effects on messenger ribonucleic acid expression by bone marrow-derived human mesenchymal stem cells seeded in agarose constructs due to ramped and steady applications of cyclic hydrostatic pressure. Tissue engineering, 13(6), 1151-1158.

Hanson, A. D., Wall, M. E., Pourdeyhimi, B., & Loboa, E. G. (2007). Effects of oxygen plasma treatment on adipose-derived human mesenchymal stem cell adherence to poly(L-lactic acid) scaffolds. Journal of biomaterials science, polymer edition, 18(11), 1387-1400.

Harrysson, O. L. A., CansiZoglu, O., Marcellin-Little, D. J., Cormier, D. R., & West, H. A. (2008). Direct metal fabrication of titanium implants with tailored materials and mechanical properties using electron beam melting technology. Materials science & engineering. C, Biomimetic materials, sensors and systems, 28(3), 366-373.

Harrysson, O., Hosni, Y. A., & Nayfeh, J. F. (2007). Custom-designed orthopedic implants evaluated using finite element analysis of patient-specific computed tomography data: femoral-component case study. BMC musculoskeletal disorders, 8, 91.

Haugh, J. M. (2008). Biophysics - Cells get in shape for a crawl. Nature, 453(7194), 461-462.

Haugh, J. M. (2007). Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology. Biophysical journal, 92(11), L93L95.

Karakoti, A. S., Monteiro-Riviere, N. A., Aggarwal, R., Davis, J. P., Narayan, R. J., Self, W. T., McGinnis, J., & Seal, S. (2008). Nanoceria as antioxidant: Synthesis and biomedical applications. JOM : the journal of the Minerals, Metals & Materials Society, 60(3), 33-37.

Kaufman, E. D., Belyea, J., Johnson, M. C., Nicholson, Z. M., Ricks, J. L., Shah, P. K., Bayless, M., Pettersson, T., Feldoto, Z., Blomberg, E., Claesson, P., & Franzen, S. (2007). Probing protein adsorption onto mercaptoundecanoic acid stabilized gold nanoparticles and surfaces by quartz crystal microbalance and zeta-potential measurements. Langmuir, 23(11), 6053-6062.

Kleinstreuer, C., Li, Z., & Farber, M. A. (2007). Fluid-structure interaction analyses of stented abdominal aortic aneurysms. Annual review of biomedical engineering, 9, 169-204.

Kleinstreuer, C., Shi, H. W., & Zhang, Z. (2007). Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology. Journal of aerosol medicine, 20(3), 294-309.

Lee, H. J., & Michielsen, S. (2007). Preparation of a superhydrophobic rough surface. Journal of polymer science. Part B, Polymer physics, 45(3), 253-261.

Lin, J. Y., Tournas, J. A., Burch, J. A., Monteiro-Riviere, N. A., & Zielinski, J. (2008). Topical isoflavones provide effective photoprotection to skin. Photodermatology, photoimmunology & photomedicine, 24(2), 61-66.

Liska, W. D., Marcellin-Little, D. J., Eskelinen, E. V., Sidebotham, C. G., Harrysson, O. L. A., & Hielm-Bjorkman, A. K. (2007). Custom total knee replacement in a dog with femoral condylar bone loss. Veterinary surgery, 36(4), 293-301.

Mauldin, F. W., Zhu, H. T., Behler, R. H., Nichols, T. C., & Gallippi, C. M. (2008). Robust principal component analysis and clustering methods for automated classification of tissue response to ARFI excitation. Ultrasound in medicine and biology, 34(2), 309-325.

McCullen, S. D., Stevens, D. R., Roberts, W. A., Clarke, L. I., Bernacki, S. H., Gorga, R. E., & Loboa, E. G. (2007). Characterization of electrospun nanocomposite scaffolds and biocompatibility with adipose-derived human mesenchymal stem cells. International journal of nanomedicine, 2(2), 253-263.

McCulloch, S. D., & Kunkel, T. A. (2008). The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell research, 18(1), 148-161.

McCullen, S. D., Stano, K. L., Stevens, D. R., Roberts, W. A., Monteiro-Riviere, N. A., Clarke, L. I., & Gorga, R. E. (2007). Development, optimization, and characterization of electrospun poly(lactic acid) nanofibers containing multi-walled carbon nanotubes. Journal of applied polymer science, 105(3), 1668-1678.

Michielsen, S., & Lee, H. J. (2007). Design of a superhydrophobic surface using woven structures. Langmuir, 23(11), 6004-6010 .

Nordone, S. K., Ignacio, G. A., Su, L. S., Sempowski, G. D., Golenbock, D. T., Li, L. W., & Dean, G. A. (2007). Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation. AIDS research and human retroviruses, 23(11), 1387-1395.

O'Neil, A. T., Monteiro-Riviere, N. A., Rouse, J. G., & Walker, G. M. (2007). A serial dilution microfluidic device for nanomaterial cytotoxicity assays. Lab animal, 7, 226-232.

Ovsianikov, A., Chichkov, B., Adunka, O., Pillsbury, H., Doraiswamy, A., & Narayan, R. J. (2007). Rapid prototyping of ossicular replacement prostheses. Applied surface science, 253(15), 6603-6607.

Ovsianikov, A., Chichkov, B., Mente, P., Monteiro-Riviere, N. A., Doraiswamy, A., & Narayan, R. J. (2007). Two photon polymerization of polymer-ceramic hybrid materials for transdermal drug delivery. International journal of applied ceramic technology, 4(1), 22-29.

Pal, A., Mbarika, V. W. A., Cobb-Payton, F., Datta, P., & McCoy, S. (2005). Telemedicine diffusion in a developing country: The case of India (March 2004). IEEE transactions on information technology in biomedicine, 9(1), 59-65.

Pfeiler, T. W., Lalush, D. S., & Loboa, E. G. (2007). Semiautomated finite element mesh generation methods for a long bone. Computer methods and programs in biomedicine, 85(3), 196-202.

Qi, J., Chi, L. Q., Faber, J., Koller, B., & Banes, A. J. (2007). ATP reduces gel compaction in osteoblast-populated collagen gels. Journal of applied physiology, 102(3), 1152-1160.

Rosenberg, E. S., Davidian, M., & Banks, H. T. (2007). Using mathematical modeling and control to develop structured treatment interruption strategies for HIV infection. Drug and alcohol dependence, 88, S41S51.

Rouse, J. G., Haslauer, C. M., Loboa, E. G., & Monteiro-Riviere, N. A. (2008). Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles. Toxicology in vitro, 22(2), 491-497.

Rouse, J. G., Yang, J. Z., Ryman-Rasmussen, J. P., Barron, A. R., & Monteiro-Riviere, N. A. (2007). Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin. Nano letters, 7(1), 155-160.

Shi, H., Kleinstreuer, C., & Zhang, Z. (2008). Dilute suspension flow with nanoparticle deposition in a representative nasal airway model. Physics of fluids (Woodbury, N.Y.), 20(1).

Smithberg, S. R., Fogle, J. E., Mexas, A. M., Reckling, S. K., Lankford, S. M., Tompkins, M. B., & Dean, G. A. (2008). In vivo depletion of CD4(+)CD25(+) regulatory T cells in cats. Journal of immunological methods, 329(1-2), 81-91.

Su, H. C., Hutchison, C. A., & Giddings, M. C. (2007). Mapping phosphoproteins in Mycoplasma genitalium and Mycoplasma pneumoniae. BMC microbiology, 7.

Traore, A. S., Guidoin, M. F., Marois, Y., Zhang, Z., Douville, Y., Guidoin, R., King, M. W., & Legrand, A. P. (2007). Newly developed hybrid suture without lubricant: Noninvasive in vivo assessment of biocompatibility with multiparametric MR imaging. Journal of investigative surgery, 20(2), 121-133.

van Aalst, J. A., Reed, C. R., Han, L., Andrady, T., Hromadka, M., Bernacki, S., Kolappa, K., Collins, J. B., & Loboa, E. G. (2008). Cellular incorporation into electrospun nanofibers - Retained viability, proliferation, and function in fibroblasts. Annals of plastic surgery, 60(5), 577-583.

Walker, G. M., Monteiro-Riviere, N., Rouse, J., & O'Neill, A. T. (2007). A linear dilution microfluidic device for cytotoxicity assays. Lab on a chip, 7(2), 226-232.

Wall, M. E., Bernacki, S. H., & Loboa, E. G. (2007). Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells. Tissue engineering, 13(6), 1291-1298.

Wall, M. E., Otey, C., Qi, J., & Banes, A. J. (2007). Connexin 43 is localized with actin in tenocytes. Cell motility and the cytoskeleton, 64(2), 121-130.

Wall, M. E., Rachlin, A., Otey, C. A., & Loboa, E. G. (2007). Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strain. American journal of physiology. Cell physiology, 293(5), C1532-C1538.

Wang, X. L., & McCord, M. G. (2007). Grafting of poly(N-isopropylacrylamide) onto nylon and polystyrene surfaces by atmospheric plasma treatment followed with free radical graft copolymerization. Journal of applied polymer science, 104(6), 3614-3621.

Wauthier, E., Schmelzer, E., Turner, W., Zhang, L., LeCluyse, E., Ruiz, J., Turner, R., Furth, M. E., Kubota, H., Lozoya, O., Barbier, C., McClelland, R., Yao, H. L., Moss, N., Bruce, A., Ludlow, J., & Reid, L. M. (2008). Hepatic stem cells and hepatoblasts: Identification, isolation, and Ex vivo maintenance. Methods in cell biology, 86, 137-+.

Xia, X. R., Baynes, R. E., Monteiro-Riviere, N. A., & Riviere, J. E. (2007). An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array. Toxicology and applied pharmacology, 221(3), 320-328.

Yan, D., Gurumurth, A., Wright, M., Pfeiler, T. W., Loboa, E. G., & Everett, E. T. (2007). Genetic background influences fluoride's effects on osteoclastogenesis. Bone, 41(6), 1036-1044.

Yang, D. M., Ramidssoon, K., Hamlett, E., & Giddings, M. C. (2008). High-accuracy peptide mass fingerprinting using peak intensity data with machine learning. Journal of proteome research, 7(1), 62-69.

Zhang, M., & Davidian, M. (2008). "Smooth" semiparametric regression analysis for arbitrarily censored time-to-event data. Biometrics, 64(2), 567-576.

Zhang, L. W., & Monteiro-Riviere, N. A. (2008). Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin pharmacology and physiology, 21(3), 166-180.

Zhang, L. W., William, W. Y. B., Colvin, V. L., & Monteiro-Riviere, N. A. (2008). Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicology and applied pharmacology, 228(2), 200-211.

Zhang, L. W., Zeng, L. L., Barron, A. R., & Monteiro-Riviere, N. A. (2007). Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes. International journal of toxicology, 26(2), 103-113 .

Zachek, M. K., Hermans, A., Wightman, R. M., & McCarty, G. S. (2008). Electrochemical dopamine detection: Comparing gold and carbon fiber microelectrodes using background subtracted fast scan cyclic voltammetry. Journal of electroanalytical chemistry, 614(1-2), 113-120.

Theses and Dissertations

Rapid Protoyping of a Single-Channel Electroencephalogram-Based Brain-Computer Interface, Adcock, David Brooks

Gene modulation during peroxisome proliferator-induced hepatocarcinogenesis, Anderson, Steven P.

An Integrated Microoptical Microfluidic Device for Agglutination Detection and Blood Typing, Alexander, Stewart Parks

Design of fully integrated wireless CMOS MEMS device for intraocular pressure measurement, Anigulu Mohan, Deepak Kumar

Not Just Another Trait: Methods for the Genetic Analysis of Gene Expression, Aylor, David Lawrence

Development of Nano-Structured Thin Film Shape Memory Alloys for MEMS Applications, Baldwin, Elizabeth Anne

Thermally Responsive Surfaces for Tissue Engineering and Apparel Applications, Barcio, Sarah

Towards predictive molecular dynamics simulations of DNA: Role of electrostatics and of the cell environment, Baucom, Jason Butler

Statistical Methods for the Analysis of Forensic DNA Mixtures, Beecham, Gary Wayne

Design and Fabrication of a MEMS Pressure Sensor and Developing a Release Protocol for MEMS, Bhate, Kaustubh Ramesh

Factors that influence the distribution of antimicrobials into the interstitial fluid as determined by in vivo ultrafiltration and pharmacokinetic modeling in dogs, Bidgood, Tara Lynn

Mechanisms of interleukin-13 induced proliferation of normal human bronchial epithelial cells in vitro, Booth, Brian William

The Effects of Neck Resection Level on the Initial Torsional Stability of Cementless Total Hip Arthroplasty in Dogs, Brooks, Daniel John

Development and Evaluation of the GIDEI USB Interface Device, Burkholder, Adam Bresler

Clustering of Mixed Data Types with Application to Toxicogenomics, Bushel, Pierre Robert

Applications of Physiologically Based Pharmacokinetic Models in Veterinary Medicine, Buur, Jennifer Leeann

Fiber Surface Modification by Particle Coating, Chhaparwal, Saurab

Keratinocyte and Hepatocyte Growth Proliferation and Adhesion to Helium and Helium/Oxygen Atmospheric Pressure Plasma Treated Polyethylene Terephthalate, Christie, Megan Allison

Statistical Methods for Family-Based Association Studies for Complex Human Diseases:  Single-Locus and Haplotype Methods, Chung, Ren-Hua

Determination of Impedance Boundary Conditions for the Pulmonary Vasculature, Clipp, Rachel Betany

Carbohydrate utilization pathway analysis in the hyperthermophile Thermotoga maritima, Conners, Shannon Burns

Refining an Elastic Constitutive Equation to Predict Aortic Pressure Distributions for Normotensive and Hypertensive Aortas, Davis, Olgha Bassam

Computational Biology of Ras Proteins, Dellinger, Andrew Everette

A Low-Power, High Performance MEMS-based Switch Fabric, Duewer, Bruce Eliot

Comparative Epidemiology of Bartonella Infection in Dogs and Humans, Duncan, Ashlee Walker

A Prototype Hadamard Imaging System, Fothergill, Daryl William

Characterizing a biomedical hydrogel device, Funke, Melissa Marie

Statistical Methods in Genetic Association Studies, Gao, Xiaoyi

A Medical Robotic System for Laser Phonomicrosurgery, Giallo, Joseph Francis

Stimuli-Responsive Protein-Based Hydrogels by Utilizing Beta-Sheet Conformation of Silk Fibroin as Cross-Links, Gil, Eun Seok

Electrospun Poly(e-caprolactone) (PCL) Nanofibrous Scaffolds for Liver Tissue Engineering, Gluck, Jessica Marie

Adhesion and mechanobiology methods to proliferate and osteogenically differentiate adipose-derived adult stem cells, Hanson, Ariel Dawn

Design of an Intelligent Compression Stocking for Reducing Ulcer Healing Time, Hegarty, Meghan Sarah

Analysis of Gene Expression Profiles with Linear Mixed Models, Hsieh, Wen-Ping

Computational methods for identifying and characterizing the human gene regulatory regions and cis-elements, Huang, Weichun

Modeling of RF Field effects due to MRI Fields in Patients with a Retinal Implant, Jasti`, Srinivas

Reasoning of Safety-Critical Medical Devices using Formal Methods, Jetley, Raoul Praful

A Conformance Review Strategy for Regulating Safety-Critical Software, Jetley, Raoul Praful

Molecular characterization of rickettsial diseases in dogs, Kidd, Linda Benjamin

Real-time characterization of III-V compound semiconductor epitaxy: application to '6.1' materials, Kim, Sungjin

Analysis of Multilocus Linkage Disequilibrium Structure in the Human Genome, Kim, Yunjung

Computational Nanofluid Flow and Heat Transfer Analyses Applied to Micro-systems, Koo, Junemo

Thrombosis and Thrombolysis: Emphasis on Hemophilia and Effect of Clot Dissolution with Plasmin, Landskroner, Kyle Alan

Design and In Vitro Evaluation of Five Epiphyseal Plate Fracture Stabilization Methods in Canines, Lee, Erica Shengkai

Microstructural, Mechanical and Antibacterial Characterization of Nanocrystalline Diamond Thin Films, Lewis, Jamal Sana

Disease Gene Mapping in General Pedigrees, Li, Li

Computational Modeling of Dose Response Relationships for Steroid Hormone Receptor-Mediated Gene Expression and Prediction of Androgen Response Element, Li, Li

Heparan sulfate proteoglycan agrin in CNS development and aging, Liu, I-Hsuan

Software and Methods for Analyzing Molecular Genetic Marker Data, Liu, Kejun

Development of Linkage and Association Methods to Map Disease Genes, Liu, Wenlei

A Point-of-Care Diagnostic Device for Quantifying Estradiol Levels in Human Saliva, Lorek, James D

Analysis on Microarray Data and DNA Regulatory Elements Prediction, Lu, Jun

Enzymatic Reactions in Water Soluble Polymer Solutions: Rheology and Kinetics, Mahammad, Shamsheer

Site-to-site rate variation in protein coding genes, Mannino, Frank Vincent

The Effectiveness of Cerclage Wiring on Stabilizing Intra-Operative Femoral Fractures During Cementless Total Hip Arthroplasty in Canines, McCulloch, Ryan McCulloch Sterling

Evolutionary Factors Shaping Haplotype and Nucleotide Diversity in Humans and Malaria, McGee, Kate

Directed Self Assembly of Nanospheres for NanoLithography and Nanostructured Surface Plasmon Sensors, McGlade, John E

Novel Methods for Mapping Complex Disease, Mei, Hao

Statistical Topics in Disease Gene Mapping, Meng, Zhaoling

Core-Sheath Differentially Biodegradable Nanofiber Structures for Tissue Engineering, Moghe, Ajit Keshav

Topical absorption and toxicity studies of jet fuel hydrocarbons in skin, Muhammad, Faqir

Functionally Gradient Hard Carbon Composites for Improved Adhesion and Wear, Narayan, Roger Jagdish

Interfacial Slippage and Fricion Studies on Material of Interest to Microelectromechanical Systems (MEMS), Neeyakorn, Worakarn

A Microfluidic Platform for Human Epidermal Keratinocyte Cytotoxicity Assays, O'Neill, Adrian Thomas

Characterization and Evaluation of a Novel Nanoporous Gold Biosensor Substrate, Pierson, Bonnie Elizabeth

Experimental determination of the non-linear, large strain zonal mechanical properties of cartilage for use in quasi-static finite element model, Prasath, Mageswaran

Heat Induced Reporter and Therapeutic Gene Expression in Cancer Gene Therapy, Pruitt, Amy Forister

Imaging properties of a rotation-free, arrayed-source micro-computed tomography system, Quan, Enzhuo

A dynamically pressurized heart model to facilitate the development of surgical tools and techniques for mitral valve repair, Richards, Andrew Latimer

Glucose and Lactate Consumption by the R3230 Mammary Adenocarcinoma, Richardson, Rachel Ann

Effects of Mechanical Stimuli on Biological Interactions with Amino Acid-Derivatized Fullerenes at the Tissue and Cellular Levels, Rouse, Jillian Grace

Finite-Difference Time-Domain Methods for Electromagnetic Problems Involving Biological Bodies, Schmidt, Stefan

Development of MEMs Micro-Bridge Mechanical Resonators Interrogated By Microcavity Interferometry, Shelton, Wilson Andrew

Quantification of Chondrocyte Apoptosis in Mechanically Impacted Articular Cartilage, Siravuri, Krishi

A Comparison of Two and Three Dimensional Wire Antennas for Biomedical Applications, Soora, Shruthi

What can RNA hybrids tell us about translation? Starmer, Joshua

The dermal absorption of selected agricultural and industrial chemicals through porcine skin with emphasis on chemical mixture effects, Van der Merwe, Deon

Vapor Phase Lubrication of MicroElectro Mechanical Systems (MEMS): An atomistic approach to solve friction and stiction in MEMS, Varma, Manju R

Responsive Biomaterial Surfaces, Wang, Xiaoling

Spectral Analysis of Protein Sequences, Wang, Zhi

Linearly Tunable RF-MEMS Capacitors Implemented Using an Integrated Removable Self-Masking Technique, Wilson, John Michael

Preparation, Characterization and Intracellular Targeting of Biomolecule-Gold Nanoparticle Complexes, Xie, Huan

Contact Material Optimization and Contact Physics in Metal-contact Microelectromechanical Systems (MEMS) Switches, Yang, Zhenyin

Improving Software Comprehension In Regulating Safety-Critical Systems, Zhang, Yi

Fumed oxide-based nanocomposite polymer electrolytes for rechargeable lithium batteries, Zhou, Jian