Applications of Computational Methods in Toxicology

Jason Pirone, Constella Health Sciences


The existence of large mathematical modeling programs at the National
Institute of Environmental Health Sciences (NIEHS), the US Environmental
Protection Agency (EPA), and the Agency for Toxic Substances and Disease
Registry (ATSDR) attests to the degree to which computational methods have
become important in toxicology.  Computational methods provide a means for
addressing the imbalance between the rapidity at which new chemicals are
introduced into the market and the time-intensive nature of traditional
testing methods.  In this talk, aspects of computational toxicology relevant
to work done at Constella in collaboration with the National Toxicology
Program (NTP) and other governmental and academic entities will be
discussed.  This talk will emphasize the uses of physiologically-based
modeling in the risk assessment process.