Publications and Patents of Daniel L. Comins

Journals

Daniel L. Comins and Alfred L. Williams, “Asymmetric Synthesis of Erythro- and Threo-2-(1-hydroxyalkyl)piperidines via Iodocyclocarbamation of 1-Acyl-2-alkenyl-1,2,3,6-tetrahydropyridines,” Tetrahedron Lett., 2000, 41, 2839.

Jeffrey T. Kuethe and Daniel L. Comins, “Addition of Metallo Enolates to Chiral 1-Acylpyridinium Salts: Total Synthesis of (+)-Cannabisativine,” Org. Lett., 2000, 2, 855.

Shenlin Huang and Daniel L. Comins, “Total Synthesis of (+)-Streptazolin,” J. Chem. Soc., Chem. Commun., 2000, 7, 569.

Clinton A. Brooks and Daniel L. Comins, “Asymmetric Synthesis of (2S, 4R)-4-Hydroxypipecolic Acid,” Tetrahedron Lett., 2000, 41, 3551.

Daniel L. Comins, Clinton A. Brooks, and Charles L. Ingalls, “Reduction of N-Acyl-2,3-dihydro-4-pyridones using Zinc/Acetic Acid,” J. Org. Chem., 2001, 66, 2181.

Daniel L. Comins, Shenlin Huang, Cheryl L. McArdle and Charles L. Ingalls, “Enantiopure 2,3-Dihydro-4-pyridones as Synthetic Intermediates: A Concise Asymmetric Synthesis of (+)-Allopumiliotoxin 267A,” Org. Lett., 2001, 3, 469.

Daniel L. Comins, Anne-Cécile Hiebel and Shenlin Huang, “Synthesis and Reactivity of N-Acyl-5-(1-hydroxyalkyl)-2,3-dihydro-4-pyridones,” Org. Lett., 2001, 3, 769.

Daniel L. Comins and Christian G. Ollinger, “Inter- and Intramolecular Horner-Wadsworth-Emmons Reactions of 5-(Diethoxyphosphoryl)-1-acyl-2-alkyl(aryl)-2,3-dihydro-4-pyridones,” Tetrahedron Lett., 2001, 42, 4115.

Daniel L. Comins, Matthew J. Sandelier, and Teresa Abad Grillo, “Asymmetric Synthesis of (+)-Desoxoprosopinine,” J. Org. Chem. Org. Chem., 2001, 66, 6829.

Daniel L. Comins and Alan B. Fulp, “Enantiopure 2,3-Dihydro-4-pyridones as Synthetic Intermediates: Asymmetric Synthesis of 1-Deoxynojirimycin,” Tetrahedron Lett., 2001, 42, 6839.

Daniel L. Comins and Alfred L. Williams, “Model Studies Toward the Total Synthesis of the Lycopodium Alkaloid, Spirolucidine,” Org. Lett., 2001, 3, 3217.

Daniel L. Comins and Jason M. Nolan, “A Practical 6-Step Synthesis of (S)-Camptothecin,” Org. Lett., 2001, 3, 4255.

Alfred L. Williams, Teresa Abad Grillo and Daniel L. Comins, “A Novel Free Radical Ring Contraction of a Cyclic Carbamate,” J. Org. Chem., 2002, 67, 1972.

Daniel L. Comins, Xiaoling Zheng and R. Richard Goehring, “Total Synthesis of the Putative Structure of the Lupin Alkaloid, Plumerinine,” Org. Lett., 2002, 4, 1611.

Daniel L. Comins, Michael O. Killpack, Emilie Despagnet and Emmanuel Zeller, “Synthesis and Reactions of Enantiopure 1-Acyl-2-(triaryl(alkyl)silyl)-2,3-dihydro-4-pyridones,” Heterocycles, 2002, 58, 505.

Sajan Joseph and Daniel L. Comins, “Synthetic Applications of Chiral 2,3-Dihydro-4-pyridones,” Current Opinion in Drug Discovery and Development, 2002, 5, 870-880.

Jeffrey T. Kuethe, Clinton A. Brooks and Daniel L. Comins*, “Diels-Alder Reactions of 5-Vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones: Regio-and Stereoselective Synthesis of Octahydroquinolines,” Org. Lett., 2003, 5, 321.

Jeffrey T. Kuethe and Daniel L. Comins, “Tandem Diels-Alder Cyclization/Aromatization Reactions of 5-Vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones,” Tetrahedron Lett., 2003, 44, 4179.

Jason M. Nolan and Daniel L. Comins, “Regioselective Sonogashira Couplings of 2,4-Dibromoquinolines. A Correction,” J. Org. Chem., 2003, 68, 3736.

Jeffrey T. Kuethe and Daniel L. Comins, “Addition of Indolyl and Pyrrolyl Grignard Reagents to 1-Acylpyridinium Salts,” J. Org. Chem., 2004, 69, 2863.

Jeffrey T. Kuethe and Daniel L. Comins, “Asymmetric Total Synthesis of (+)-Cannabisativine,” J. Org. Chem., 2004, 69, 5219.

Dimitar B. Gotchev and Daniel L. Comins, “Novel Heterocyclic Systems. Synthesis of 2,7-Dimethyl-10-oxa-1,8-diaza-anthracen-9-one and Derivatives,” Tetrahedron, 2004, 60, 11751.

Daniel L. Comins, Sean O’Connor, and Jason Dinsmore, “Six-Membered Ring Systems: Pyridine and Benzo Derivatives,” in Progress in Heterocyclic Chemistry, Vol. 16, G. W. Gribble and J. A. Joule, Eds.; Pergamon Press, Oxford, England, 2004.

Daniel L. Comins, Stefan Schilling and Yanchen Zhang, “Asymmetric Synthesis of 3-Substituted Isoindolinones: Application to the Total Synthesis of (+)-Lennoxamine,” Org. Lett., 2005, 7, 95.

Daniel L. Comins, Jeffrey T. Kuethe, Teresa M. Miller, Florence C. Février, and Clinton A. Brooks, “Diels-Alder Reactions of N-Acyl-2-alkyl(aryl)-5-vinyl-2,3-dihydro-4-pyridones,” J. Org. Chem., 2005, 70, 5221.

Daniel L. Comins and Anne-Cécile Hiebel, “Asymmetric Synthesis of 3,3-Disubstituted Isoindolinones,” Tetrahedron Lett., 2005, 46, 5639.

Daniel L. Comins, Jason M. Nolan and Ibrahim D. Bori, “Regioselective Lithium-Halogen Exchange and Palladium-catalyzed Cross-Coupling Reactions of 2,4-Dihaloquinolines,” Tetrahedron Lett., 2005, 46, 6697.

Daniel L. Comins, Laura S. King, Emilie D. Smith, and Florence C. Février, “Synthesis of C-4 Substituted Nicotine Derivatives via an N-Acylpyridinium Salt of (S)-Nicotine,” Org. Lett., 2005, 7, 5059.

Daniel L. Comins and James J. Sahn, “A Six-Step Synthesis of (+)-Hyperaspine,” Org. Lett., 2005, 7, 5227.

Florence C. Février, Emilie D. Smith, and Daniel L. Comins, “Regioselective C-2 and C-6 Substitution of (S)-Nicotine and Nicotine Derivatives,” Org. Lett., 2005, 7, 5457.

Damian W. Young and Daniel L. Comins, “Tandem Directed Lithiations of N-Boc-1,2-dihydropyridines toward Highly Functionalized 2,3-Dihydro-4-pyridones,” Org. Lett., 2005, 7, 5661.

Emilie D. Smith, Florence C. Février and Daniel L. Comins, “Synthesis of Nicotine Derivatives via Reductive Disilylation of (S)-Nicotine,” Org. Lett., 2006, 8, 179.

Daniel L. Comins and Emilie D. Smith, “A Six-Step Synthesis of (S)-5-Ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-Nicotine,” Tetrahedron Lett., 2006, 47, 1449.

Florence F. Wagner and Daniel L. Comins, “Regioselective Substitution at the C-5, C-4 and C-2 Positions of (S)-6-Chloronicotine and C-4 Substitution of (S)-5-Chloronicotine,” Eur. J. Org. Chem., 2006, 3562.

Florence F. Wagner and Daniel L. Comins, “Six-Step Synthesis of (S)-Brevicolline from (S)-Nicotine,” Org. Lett., 2006, 8, 3549.

Dimitar B. Gotchev and Daniel L. Comins, “Synthetic Studies Toward (-)-FR901483 Using a Conjugate Allylation to Install the C-1 Quaternary Carbon,” J. Org. Chem., 2006, 71, 9393.

Florence F. Wagner and Daniel L. Comins, “Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine,” J. Org. Chem., 2006, 71, 8673.

Christof F. Stumpf, Daniel L. Comins, Thomas C. Sparks, Kevin V. Donohue, and R. Michael Roe, “Insecticidal activity and mode of action of novel neonicotinoids synthesized by new acylpyridinium salt chemistry and directed lithiation,” Pesticide Biochemistry and Physiology, 2007, 87, 211.

Jennifer L. Frahm, Ibrahim D. Bori, Daniel L. Comins, Adam M. Hawkridge and David C. Muddiman, “Achieving Augmented Limits of Detection for Peptides with Hydrophobic Alkyl Tags (ALiPHAT),” Anal. Chem., 2007, 79, 3989.

Florence F. Wagner and Daniel L. Comins, “Recent Advances in the Synthesis of Nicotine and its Derivatives,” Tetrahedron, 2007, 63, 8065.

Daniel L. Comins, Jason M. Dinsmore, and Lucas R. Marks, “One-pot Terminal Alkene Homologation using a Tandem Olefin Cross Metathesis/Allylic Carbonate Reduction Sequence,” Chem. Commun., 2007, 4170.

Daniel L. Comins and Kazuhiro Higuchi, “Synthesis of Benzo-fused Indolizidine Alkaloid Mimics,” Beil. J. Org. Chem., 2007, 3:42.

Pauline W. Ondachi and Daniel L. Comins, “Synthesis and Regioselective Substitution of C-6 Alkoxy Derivatives of (S)-Nicotine,” Tetrahedron Lett., 2008, 49, 569.

Pandi Bharathi and Daniel L. Comins, “Asymmetric Synthesis of C2-Symmetric Vicinal Diamines via Reductive Dimerization of N-Acylpyridinium and Related Salts,” Org. Lett., 2008, 10, 221.

Williams, D. Keith, Jr., Corey W. Meadows, Ibrahim D. Bori, Adam M. Hawkridge, Daniel L. Comins, and David C. Muddiman, “Synthesis, Characterization, and Application of Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy,” J. Am. Chem. Soc., 2008, 130, 2122.

Dorit Eliyahu, Satoshi Nojima, Sonja S. Capracotta, Daniel L. Comins and Coby Schal, “Identification of Cuticular Compounds Responsible for Eliciting Interspecific Courtship Behavior in the Male German Cockroach, Blattella germanica,” Naturwissenschaften, 2008, 95, 403.

Daniel L. Comins, Sean O’Connor, Rima S. Al-Awar, Pyridines and their Benzo Derivatives: Reactivity at the Ring. In Comprehensive Heterocyclic Chemistry III, A. R. Katritzky, C. A. Ramsden, EFV Scriven and RJK Taylor, Eds.; Elsevier: Oxford, 2008; Vol. 7, pp 41-100.

W. Stephen McCall, Teresa Abad Grillo and Daniel L. Comins, “Stereoselective Synthesis of Acyclic Amino Alcohols via von Braun Ring Opening of Chiral Piperidines,” Org. Lett., 2008, 10, 3255.

W. Stephen McCall, Teresa Abad Grillo and Daniel L. Comins, “N-Acyl-dihydropyridones as Synthetic Intermediates. A Stereoselective Synthesis of Acyclic Amino Alcohols Containing Multiple Chiral Centers,” J. Org. Chem., 2008, 73, 9744.

Sonja S. Capracotta and Daniel L. Comins, “Chiral Amino Alcohols Derived from (S)-6-Chloronicotine as Catalysts for Asymmetric Synthesis,” Tetrahedron Lett., 2009, 50, 1806.

W. Stephen McCall and Daniel L. Comins, “Synthesis of 1,3-Amino Alcohol Derivatives via a Silicon-mediated Ring Opening of Substituted Piperidines,” Org. Lett., 2009, 11, 2940.

D. Keith Williams Jr., Daniel L. Comins, Jerry L. Whitten, and David C. Muddiman, “Evaluation of the ALiPHAT Method for PC-IDMS and Correlation of Limits-of-Detection with Nonpolar Surface
Area,” J. Am. Soc. Mass. Spectrom., 2009, 20, 2006.

Michael S. Bereman, Daniel L. Comins and David C. Muddiman, “Increasing the Hydrophobicity and Electrospray Response of Glycans through Derivatization with Novel Reagents,” Chem. Comm., 2010, 46, 237.

Christopher M. Shuford, Daniel L. Comins, Jerry L. Whitten, John C. Burnett, Jr., and David C. Muddiman, “Improving Limits of Detection for B-type Natriuretic Peptide Using PC-IDMS: An Application of the ALiPHAT Strategy,” Analyst, 2010, 135, 36.

Pauline W. Ondachi and Daniel L. Comins, “Synthesis of Fused-Ring Nicotine Derivatives from (S)-Nicotine,” J. Org. Chem., 2010, 75, 1706.

Venita Gresham, Alison Motsinger-Reif, Nicholas E. Hardison, Eric J. Peters, Tammy M. Havener, Lorraine Everitt, James Todd Auman, Daniel L. Comins and Howard L. McLeod, “Identification and Replication at Loci involved in Camptothecin-Induced Cytotoxicity using CEPH Pedigrees,” Hum. Mol. Genet., 2011, in press.

Steven Walker, Brian Papas, Daniel L. Comins and David C. Muddiman, “The Interplay of Permanent Charge and Hydrophobicity in the Electrospray Ionization of Glycans,” Anal. Chem., 2010, 82, 6636.

James J. Sahn and Daniel L. Comins, “[2+2] Photochemical Gycloaddition/Ring Opening of 6-Alkenyl-2,3-dihydro-4-pyridones,” J. Org. Chem., 2010, 75, 6728.

Monica F. Enamorado, Pauline W. Ondachi and Daniel L. Comins, “A Five Step Synthesis of (S)-Macrostomine from (S)-Nicotine,” Org. Lett. 2010, 12, 4513.

Bradley H. Wolfe, Adam H. Libby, Rima S. Al-awar, Christopher J. Foti and Daniel L. Comins, “Asymmetric Synthesis of All the Known Phlegmarine Alkaloids,” J. Org. Chem. 2010, 75, 8564.

S. Hunter Walker, Laura M. Lilley, Monica F. Enamorado, Daniel L. Comins, David C. Muddiman, “Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry,” J. Am. Soc. Mass. Spectrom., 2011, 22, 1309.

Sergey V. Tsukanov and Daniel L. Comins, “Concise Total Synthesis of the Frog Alkaloid (-)-205B,” Angew. Chem., Int. Ed. Engl., 2011, 8626.

James J. Sahn, Pandi Bharathi and Daniel L. Comins, &ldquoStudies toward the Synthesis of Spirolucidine. Preparation of ABC and EF Ring Fragments,” Tetrahedron Lett. 2012, 53, 1347.

BOOK CHAPTERS AND REVIEW ARTICLES (INVITED)

1. Comins and Sean O’Connor, “Regioselective Substitution in Aromatic 6-Membered Nitrogen Heterocycles”, in Advances in Heterocyclic Chemistry, Vol. 44, A. R. Katritzky, Ed., Academic Press, New York, N.Y., 1988.

2. Daniel L. Comins, “The Synthetic Utility of α-Amino Alkoxides,” invited Account, Synlett, 615-625, 1992.

3. Daniel L. Comins and Sajan P. Joseph, “N,N-Dimethylformamide, N-Methylformanilide, N-Formylpiperidine, 2-(N-Formyl-N-Methyl)aminopyridine, Lithium morpholide, N-Lithio-N, N',N'-trimethylenthylenediamine and Lithium N-methylpiperazide,” in Encyclopedia of Reagents for Organic Synthesis, L.A. Paquette, Ed.; Wiley, 1996.

4. Daniel L. Comins and Sajan P. Joseph, “Chemistry of Pyridines at Ring Positions,” in Comprehensive Heterocyclic Chemistry: Second Edition, Vol. 5, A. McKillop, Ed. Pergamon Press, Oxford, England, 1996.

5. Daniel L. Comins and Sajan P. Joseph, “Dihydropyridones as Building Blocks for Alkaloid Synthesis,” in Advances in Nitrogen Heterocycles, Vol. 2, C.J. Moody, Ed., JAI Press, Greenwich, Connecticut, 1996.

6. Daniel L. Comins and Sean O’Connor, “Six-Membered Ring Systems: Pyridine and Benzo Derivatives,” in Progress in Heterocyclic Chemistry, Vol. 9, H. Suschitzky and G. W. Gribble, Eds.; Pergamon Press, Oxford, England, 1997.

7. Sajan Joseph and Daniel L. Comins, “Synthetic Applications of Chiral 2,3-Dihydro-4-pyridones,” Current Opinion in Drug Discovery and Development, 2002, 5, 870-880..

8. Daniel L. Comins, Sean O’Connor, and Jason Dinsmore, “Six-Membered Ring Systems: Pyridine and Benzo Derivatives,” in Progress in Heterocyclic Chemistry, Vol. 16, G. W. Gribble and J. A. Joule, Eds.; Pergamon Press, Oxford, England, 2004.

9. Florence F. Wagner and Daniel L. Comins, “Recent Advances in the Synthesis of Nicotine and its Derivatives,” Tetrahedron Report, 2007, 63, 8065.

10. Daniel L. Comins, Sean O’Connor, and Rima S. Al-awar, “Chemistry of Pyridines at Ring Positions,” in Comprehensive Heterocyclic Chemistry III, AR Katritzky, CA Ramsden, EFV Scriven and RJK Taylor, Eds.; Elsevier: Oxford, 2008, Vol. 7, pp 41-100.

11. Daniel L. Comins and Sergey Tsukanov, “Applications to Alkaloid Synthesis.” In Pyridines: from lab to production; Scriven, E. F. V., Ed.; Elsevier Ltd: Academic Press, 2013; pp 459–496.

Patents

1. Daniel L. Comins and Matthew F. Baevsky, “Intermediates and Method of Making Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,162,532 (1992).

2. Daniel L. Comins and Matthew F. Baevsky, “Camptothecin Intermediates and Method of Making Camptothecin Intermediates,” U.S. Patent No. 5,191,082 (1993).

3. Daniel L. Comins and Matthew F. Baevsky, “Camptothecin Intermediates and Method of Making Same,” U.S. Patent No. 5,200,524 (1993).

4. Daniel L. Comins and Matthew F. Baevsky, “Method of Making [Asymmetric] Camptothecin and Camptothecin Analogs”, U.S. Patent No. 5,212,317 (1993).

5. Daniel L. Comins and Matthew F. Baevsky, “Alkylpyridone DE Ring Intermediates Useful for the Manufacture of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,243,050 (1993).

6. Daniel L. Comins and Matthew F. Baevsky, “Method of Making Intermediates Useful for the Manufacture of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,247,089 (1993).

7. Daniel L. Comins and Matthew F. Baevsky, “Alkoxymethylpyridine D-Ring Intermediates Useful for the synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,254,690 (1993).

8. Daniel L. Comins and Matthew F. Baevsky, “Synthesis of Optically Pure D, E Ring Intermediates Useful for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,258,516 (1993).

9. Daniel L. Comins and James M. Salvador, “Cycloalkyl-Based Chiral Auxiliaries and Method of Making the Same,” U.S. Patent No. 5,262,571 (1993).

10. Daniel L. Comins and Matthew F. Baevsky, “D Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,262,579 (1993).

11. Daniel L. Comins and Matthew F. Baevsky, “Process for Making DE Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,315,007 (1994).

12. Daniel L. Comins and Matthew F. Baevsky, “Pyridinecarboxaldehyde D-Ring Intermediates Useful for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,321,140 (1994).

13. Daniel L. Comins, “Method of Making Asymmetric DE Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,395,939 (1995).

14. Daniel L. Comins, “Method of Making Asymmetric DE Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,428,166 (1995).

15. Daniel L. Comins, “14-Halo-Camptothecins,” U.S. Patent No. 5,459,269 (1995).

16. Daniel L. Comins and Matthew F. Baevsky, “Camptothecin Intermediates and Method of Making Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,475,108 (1995).

17. Daniel L. Comins and Matthew F. Baevsky, “Method of Making Intermediates for Camptothecin and its Analogs,” U.S. Patent No. 5,478,943 (1995).

18. Daniel L. Comins, “Method of Making Asymmetric DE Ring Intermediates for the Synthesis of Camptothecin Analogs,” U.S. Patent No. 5,486,615 (1996).

19. Daniel L. Comins, “Method of Making Asymmetric DE Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,496,952 (1996).

20. Daniel L. Comins and Matthew F. Baevsky, “Method of Making Camptothecin and Camptothecin Analogs,” Canadian Patent No. 2,112,351(1998).

21. Francis G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, “Preparation of Camptothecin Derivative by Intramolecular Cyclisation,” U.S. Patent No. 6,063,923 (2000).

22. Frances G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, “Preparation of a Camptothecin Derivative by Intramolecular Cyclization,” U.S. Patent No. 6,462,196 (2002).

23. Daniel L. Comins and Shenlin Huang, “A Short Synthesis of Pyridine-Based Pharmaceutical Intermediates,” U.S. Patent No. 6,534,656 (2003).

24. Frances G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, “Preparation of a Camptothecin Derivative by Intramolecular Cyclization,” U.S. Patent No. 6,559,309 (2003).

25. Daniel L. Comins and Shenlin Huang, “Short Synthesis of Pyridine-Based Pharmaceutical Intermediates,” U.S. Patent No.: 6,706,884 (2004).

26. Daniel L. Comins and Shenlin Huang, “Short Synthesis of Pyridine-Based Pharmaceutical Intermediates,” U.S. Patent No. 6,855,825 (2005).

27. Daniel L. Comins and Shenlin Huang, “Short Synthesis of Pyridine-Based Pharmaceutical Intermediates,” U.S. Patent No. 6,987,189 (2006).

28. Daniel L. Comins and Emilie Despagnet, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No. 6,995,265 (2006).

29. Comins, Daniel L., Florence C. Février, and Emilie Despagnet, “Regioselective Halogenation of Nicotine and Substituted Nicotines,” U.S. Patent No.: 7,067,672 (2006).

30. Laura S. King, Emilie Despagnet and Daniel L. Comins, “Regiospecific Synthesis of Nicotine Derivatives,” U.S. Patent No.: 7,112,678 (2006).

31. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No.: 7,132,545 (2006).

32. Daniel L. Comins, Florence Février, and Emilie Despagnet Smith, “Regioselective Halogenation of Nicotine and Substituted Nicotines,” U.S. Patent No.: 7,179,917 (2007).

33. Laura S. King, Emilie Smith, and Daniel L. Comins, “Regiospecific Synthesis of Nicotine Derivatives,” U.S. Patent No.: 7,304,160 (2007).

34. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No. 7,361,768 (2008).

35. Daniel L. Comins, Florence C. Février, and Emilie D. Smith, “Regioselective Halogenation of Nicotine and Substituted Nicotines,” U.S. Patent No. 7,501,520 (2009).

36. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No. 7,553,968 (2009).

37. Laura S. King, Emilie D. Smith, and Daniel L. Comins, “Regiospecific Synthesis of Nicotine Derivatives,” U.S. Patent No. 7,671,209 (2010).

38. Daniel L. Comins, Florence C. Février, and Pauline Ondachi, “Synthesis and Regioselective Substitution of 6-Halo- and 6-Alkoxy Nicotine Derivatives,” U.S. Patent No. 7,820,826 (2010).

39. Laura S. King, Emilie D. Smith, and Daniel L. Comins, “Regiospecific Synthesis of Nicotine Derivatives,” U.S. Patent No. 7,875,724 (2011).

40. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No. 7,888,512 (2011).

Patent Applications

1. Daniel L. Comins and Sonja S. Capracotta, “Nicotine-based Compounds Useful for Asymmetric Synthesis,” U.S. Provisional Patent Application No. 61/102,516 (2008).

2. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent Application No. 12/472626.

3. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent Application Publication No. US 2009 0234129 A1.

4. Daniel L. Comins and Sonja S. Capracotta, “Nicotine-based Compounds Useful for Asymmetric Synthesis,” US Patent Application No. US 2008/102516.