A Mathematical Model of Cellular Signaling Kinetics

Mary Ann Horn
National Science Foundation

Focusing on signaling pathways in a macrophage-like cell line, mathematical models provide insight into the structure and function of complex cellular interactions. Activation of cell surface G-protein coupled receptors initiates diverse cellular signaling responses including mobilization of internal calcium, cyclic adenosine monophosphate modulation, and activation of lipid hydrolases and kinases. These signaling pathways interact with one another, often in a nonlinear manner, and the final biological response is shaped by the nature of these interactions. Recently, there has been significant progress in modeling individual components of such pathways and our goal has been the construction of a comprehensive mathematical model for one particular signaling pathway of significant interest to pharmacology. The development of the model and its impact on the understanding of the underlying biology will be discussed.

Back to the program