Presenter: Marcus A. Hunt
Advisor(s): C. Maurice Balik
Author(s): Marcus A. Hunt, Alan E. Tonelli, C. Maurice Balik
Graduate Program: Fiber and Polymer Science,
Fiber and Polymer Science, Materials Science and Engineering

Title: Solid-State Complexation of Polymer-Cyclodextrin Inclusion Complexes

Abstract: alpha-Cyclodextrin (alpha-CD), a cyclic oligosaccharide, in the solid state forms an inclusion complex with poly(ethylene glycol) (PEG). The transformation of alpha-CD from cage to columnar structure upon exposure to PEG and ambient water is tracked with wide-angle X-ray diffraction. A first-order kinetic model is used to describe the kinetics of the transformation as a function of water activity. The extent of conversion from cage to columnar structure reaches a maximum at a water activity of 0.5, while the rate of conversion is largest at high water activities. Solid-state complexation of hexatriacontane with alpha-CD was also prepared to determine the role of water in the inclusion complex formation process.